期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：2
页码：639-644
DOI：10.1073/pnas.0909503107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：G-protein {beta}{gamma} (G{beta}{gamma}) subunits interact with a wide range of molecular partners including: G[α] subunits, effectors, peptides, and small molecule inhibitors. The molecular mechanisms underlying the ability to accommodate this wide range of structurally distinct binding partners are not well understood. To uncover the role of protein flexibility and alterations in protein conformation in molecular recognition by G{beta}{gamma
