期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：25
页码：11614-11619
DOI：10.1073/pnas.1000438107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The metazoan circadian clock mechanism involves cyclic transcriptional activation and repression by proteins whose degradation is highly regulated via the ubiquitin-proteasome pathway. The heme receptor Rev-erb[α], a core negative component of the circadian network, controls circadian oscillation of several clock genes, including Bmal1 Rev-erb[α] protein degradation can be triggered by inhibitors of glycogen synthase kinase 3{beta
