期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：31
页码：13888-13893
DOI：10.1073/pnas.1009038107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Alzheimer's disease (AD) brains are characterized by amyloid-{beta}-containing plaques and hyperphosphorylated tau-containing neurofibrillary tangles (NFTs); however, in frontotemporal dementia, the tau pathology manifests in the absence of overt amyloid-{beta} plaques. Therapeutic strategies so far have primarily been targeting amyloid-{beta
