期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：34
页码：15099-15104
DOI：10.1073/pnas.1010018107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：High-content screening for small-molecule inducers of insulin expression identified the compound BRD7389, which caused -cells to adopt several morphological and gene expression features of a {beta}-cell state. Assay-performance profile analysis suggests kinase inhibition as a mechanism of action, and we show that biochemical and cellular inhibition of the RSK kinase family by BRD7389 is likely related to its ability induce a {beta}-cell-like state. BRD7389 also increases the endocrine cell content and function of donor human pancreatic islets in culture.
