期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：35
页码：15553-15558
DOI：10.1073/pnas.0914072107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor and a central mediator of the unfolded protein response. In a human glioma model, inhibition of IRE1{alpha} correlated with down-regulation of prevalent proangiogenic factors such as VEGF-A, IL-1{beta
关键词：tumor ischemia ; unfolded protein response ; mesenchymal drift
