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  • 标题:Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock
  • 本地全文:下载
  • 作者:Satoru Masubuchi ; Tianyan Gao ; Audrey O'Neill
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2010
  • 卷号:107
  • 期号:4
  • 页码:1642-1647
  • DOI:10.1073/pnas.0910292107
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) differentially attenuates Akt, PKC, and ERK1/2 signaling, thereby controlling the duration and amplitude of responses evoked by these kinases. PHLPP1 is expressed in the mammalian central clock, the suprachiasmatic nucleus, where it oscillates in a circadian fashion. To explore the role of PHLPP1 in vivo, we have generated mice with a targeted deletion of the PHLPP1 gene. Here we show that PHLPP1-null mice, although displaying normal circadian rhythmicity, have a drastically impaired capacity to stabilize the circadian period after light-induced resetting, producing a large phase shift after light resetting. Our findings reveal that PHLPP1 exerts a previously unappreciated role in circadian control, governing the consolidation of circadian periodicity after resetting.
  • 关键词:Per ; period ; after-effect ; suprachiasmatic nucleus ; phase shift
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