期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2010
卷号：107
期号：5
页码：2171-2176
DOI：10.1073/pnas.0909384107
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：IL-2 is crucial to T cell homeostasis, especially of CD4+ T regulatory cells and memory CD8+ cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor {alpha} (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis.
关键词：CD25 ; cytokine ; cytokine/mAb complexes ; T cell homeostasis ; Fc receptor
