期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：23
页码：13573-13578
DOI：10.1073/pnas.2233084100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Androgens may regulate the male skeleton either directly by stimulation of the androgen receptor (AR) or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen receptors (ERs). To directly compare the effect of ER activation on bone in vivo with the effect of AR activation, 9-month-old orchidectomized wild-type and ER-inactivated mice were treated with the nonaromatizable androgen 5-dihydrotestosterone, 17{beta}-estradiol, or vehicle. Both ER and AR but not ER{beta} activation preserved the amount of trabecular bone. ER activation resulted both in a preserved thickness and number of trabeculae. In contrast, AR activation exclusively preserved the number of trabeculae, whereas the thickness of the trabeculae was unaffected. Furthermore, the effects of 17{beta}-estradiol could not be mediated by the AR, and the effects of 5-dihydrotestosterone were increased rather than decreased in ER-inactivated mice. ER, but not AR or ER{beta
