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  • 标题:The laminin receptor modulates granulocyte–macrophage colony-stimulating factor receptor complex formation and modulates its signaling
  • 本地全文:下载
  • 作者:Jian Chen ; Juan M. Cárcamo ; Oriana Bórquez-Ojeda
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2003
  • 卷号:100
  • 期号:24
  • 页码:14000-14005
  • DOI:10.1073/pnas.2334584100
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Basement membrane matrix proteins are known to up-regulate granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling in neutrophils and mononuclear phagocytes, but the mechanisms involved are poorly understood. We used the intracellular portion of the subunit of the GM-CSF receptor (GMR) to search for interacting proteins and identified the 67-kDa laminin receptor (LR), a nonintegrin matrix protein receptor expressed in several types of host defense cells and certain tumors, as a binding partner. LR was found to interact with the {beta} subunit of the GMR ({beta}GMR) as well. Whereas GM-CSF functions by engaging the GMR and {beta}GMR into receptor complexes, LR inhibited GM-CSF-induced receptor complex formation. Laminin and fibronectin binding to LR was found to prevent the binding of {beta}GMR to LR and relieved the LR inhibition of GMR. These findings provide a mechanistic basis for enhancing host defense cell responsiveness to GM-CSF at transendothelial migration sites while suppressing it in circulation.
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