期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：3
页码：1280-1285
DOI：10.1073/pnas.0237385100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The cholera toxin genes of Vibrio cholerae are encoded by the filamentous phage, CTX{Phi}. Chromosomal CTX{Phi} prophage DNA is often found flanked by copies of a related genetic element designated RS1, and RS1 DNA can be packaged into filamentous phage particles (designated RS1{Phi}) by using the CTX{Phi} morphogenesis genes. RS1{Phi} is a satellite phage that further controls expression and dissemination of CTX{Phi}. Here we describe a CTX{Phi}-independent mechanism for production of RS1{Phi}. A nontoxigenic environmental V. cholerae strain (55V71) was identified that supports production of RS1{Phi}. However, newly infected CTX-negative strains did not produce RS1{Phi
