期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：3
页码：1370-1374
DOI：10.1073/pnas.0337529100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling? Interneuron gap junctions enhance synchrony of {gamma} oscillations (25-70 Hz) in isolated interneuron networks and also in networks containing both interneurons and principal cells, as shown in mice with a knockout of the neuronal (primarily interneuronal) connexin36. We have recently shown that pharmacological gap junction blockade abolishes kainate-induced {gamma} oscillations in connexin36 knockout mice; without such gap junction blockade, {gamma} oscillations do occur in the knockout mice, albeit at reduced power compared with wild-type mice. As interneuronal dendritic electrical coupling is almost absent in the knockout mice, these pharmacological data indicate a role of axonal electrical coupling in generating the {gamma} oscillations. We construct a network model of an experimental {gamma} oscillation, known to be regulated by both types of electrical coupling. In our model, axonal electrical coupling is required for the {gamma} oscillation to occur at all; interneuron dendritic gap junctions exert a modulatory effect.
