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  • 标题:Permeation-driven flow in poly(dimethylsiloxane) microfluidic devices
  • 本地全文:下载
  • 作者:Greg C. Randall ; Patrick S. Doyle
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2005
  • 卷号:102
  • 期号:31
  • 页码:10813-10818
  • DOI:10.1073/pnas.0503287102
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Poly(dimethylsiloxane) is currently the material of choice for rapidly fabricating microfluidic devices. As the size of these devices decreases, a significant hydrodynamic flow is generated due to permeation of fluid through the channel walls. We develop a theoretical model verified by single bead tracking experiments, which demonstrates that large flow rates (>10 {micro}m/s) can be passively generated in a straight microchannel filled with water. Realizing that this flow may be unwanted in some applications, we present a method to eliminate it by inhibiting mass transfer of water into the poly(dimethylsiloxane) walls. Furthermore, we explore applications to harness this passively generated flow inside a microfluidic device such as bead stacking, chemical concentration, and passive pumping.
  • 关键词:fluid dynamics ; soft lithography
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