期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2006
卷号：103
期号：31
页码：11736-11741
DOI：10.1073/pnas.0604575103
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：We have demonstrated that cytokine thymic stromal lymphopoietin (TSLP), whose expression is rapidly induced upon keratinocyte-selective ablation of retinoid X receptors (RXRs) -{alpha} and -[beta] in the mouse (RXR{alpha}[beta]ep-/- mice), plays a key role in initiating a skin and systemic atopic dermatitis-like phenotype. We show here that topical application of the physiologically active ligand [1{alpha
关键词：retinoic acid ; vitamin D receptor ; retinoid X receptor ; retinoic acid receptor ; skin
