期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2008
卷号：105
期号：41
页码：15890-15895
DOI：10.1073/pnas.0803171105
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Interferon regulatory factor (IRF) 4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4+ T cells into Th2 and Th17 cells. Using the infection model of Nippostrongyrus brasiliensis, we have confirmed the critical roles of IRF-4 in Th2 development in vivo by using IRF-4-/- BALB/c mice. However, naive IRF-4-/-CD4+ T cells produced Th2 cytokines, including IL-4, IL-5, and IL-10, but not IL-2 or IFN-{gamma
