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  • 标题:Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging
  • 本地全文:下载
  • 作者:S Ogawa ; D W Tank ; R Menon
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1992
  • 卷号:89
  • 期号:13
  • 页码:5951-5955
  • DOI:10.1073/pnas.89.13.5951
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T*2. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.
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