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  • 标题:Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate
  • 本地全文:下载
  • 作者:H Matsue ; K G Rothberg ; A Takashima
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1992
  • 卷号:89
  • 期号:13
  • 页码:6006-6009
  • DOI:10.1073/pnas.89.13.6006
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The folate receptor mediates the uptake of 5-methyltetrahydrofolate in certain cultured cells by a process called potocytosis. When these cells are grown in physiological concentrations of folate, the receptor increases the efficiency of vitamin uptake by 30-fold. We now show that PAM 212 cells, a mouse keratinocyte cell line, are unable to grow in 1 nM 5-methyltetrahydrofolate unless they express a functional folate receptor. These results suggest that under certain conditions, tissue cells in the body may depend on the folate receptor to obtain enough 5-methyltetrahydrofolate for growth.
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