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  • 标题:Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate
  • 本地全文:下载
  • 作者:H Kimura ; D Schubert
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1993
  • 卷号:90
  • 期号:16
  • 页码:7508-7512
  • DOI:10.1073/pnas.90.16.7508
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The biological function of the soluble form of the amyloid beta-protein (ABP) was examined by assaying its interaction with neuronal receptors expressed in Xenopus oocytes. ABP weakly activated tachykinin receptors, but in the presence of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4- propionate-type glutamate receptors ABP-induced responses were greatly enhanced. Glutamate and ABP together also induced accumulation of inositol trisphosphate and increases in intracellular Ca2+. These observations suggest that in the presence of glutamate, ABP can activate tachykinin receptors and phosphatidylinositol turnover. ABP may therefore act as a neuromodulatory peptide.
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