首页    期刊浏览 2024年11月09日 星期六
登录注册

文章基本信息

  • 标题:Prevention of autoimmune lysis by T cells with specificity for a heat shock protein by antisense oligonucleotide treatment
  • 本地全文:下载
  • 作者:U Steinhoff ; U Zügel ; A Wand-Württenberger
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1994
  • 卷号:91
  • 期号:11
  • 页码:5085-5088
  • DOI:10.1073/pnas.91.11.5085
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:T lymphocytes with specificity for the bacterial heat shock protein (hsp) 60 recognize stressed host cells, thus possibly promoting pathogenesis of certain infectious and autoimmune diseases. Here, we show that autoimmune destruction of stressed Schwann cells and macrophages by cytotoxic T lymphocytes raised against mycobacterial hsp60 can be inhibited by the use of hsp60-specific antisense oligodeoxynucleotides (A-ODNs). The inhibitory effect of hsp60 A-ODNs was specific because lysis of murine cytomegalovirus-infected host cells by virus-specific cytotoxic lymphocytes was not affected. Immunoblot analysis and immunoprecipitation studies suggest that different forms of stress increase hsp60 synthesis in Schwann cells and that this neosynthesis is reduced by hsp60 A-ODNs. These findings (i) provide evidence for participation of endogenous hsp60 in the recognition of stressed host cells by mycobacterial hsp60-crossreactive T cells and (ii) suggest the feasibility of inhibiting autoimmune reactions by target-cell treatment with specific A-ODNs.
国家哲学社会科学文献中心版权所有