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  • 标题:Enteric immunization of mice against influenza with recombinant vaccinia
  • 本地全文:下载
  • 作者:C A Meitin ; B S Bender ; P A Small
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1994
  • 卷号:91
  • 期号:23
  • 页码:11187-11191
  • DOI:10.1073/pnas.91.23.11187
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Intrajejunal administration to mice of a recombinant vaccinia virus containing the influenza virus hemagglutinin gene induced IgA antibody in nasal, gut, and vaginal secretions. It also induced IgG antibody in serum and cell-mediated immunity. The immunization provided significant protection against an influenza virus challenge. This work suggests that enteric-coated recombinant vaccinia could be an orally administered, inexpensive, multivalent, temperature-stable, safe, and effective vaccine for children that could be particularly useful in developing nations, where multiple injections are not easily administered. Oral administration of vaccines should also reduce children's fear of shots at the doctor's office.
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