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  • 标题:Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA
  • 本地全文:下载
  • 作者:R O Dempcy ; J Luo ; T C Bruice
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:1996
  • 卷号:93
  • 期号:9
  • 页码:4326-4330
  • DOI:10.1073/pnas.93.9.4326
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].
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