期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2000
卷号：97
期号：24
页码：13275-13280
DOI：10.1073/pnas.97.24.13275
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：There is evidence from both genetic and pharmacologic studies to suggest that the cyclooxygenase-2 (COX-2) enzyme plays a causal role in the development of colorectal cancer. However, little is known about the identity or role of the eicosanoid receptor pathways activated by COX-derived prostaglandins (PG). We previously have reported that COX-2-derived prostacyclin promotes embryo implantation in the mouse uterus via activation of the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR) {delta}. In light of the recent finding that PPAR{delta} is a target of {beta}-catenin transactivation, it is important to determine whether this signaling pathway is operative during the development of colorectal cancer. Analysis of PPAR{delta} mRNA in matched normal and tumor samples revealed that expression of PPAR{delta
