期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2001
卷号：98
期号：15
页码：8355-8360
DOI：10.1073/pnas.121007298
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：DNA polymerase {eta} (Pol{eta}) functions in the error-free bypass of UV-induced DNA lesions, and a defect in Pol{eta} in humans causes the cancer-prone syndrome, the variant form of xeroderma pigmentosum. Both yeast and human Pol{eta} replicate through a cis-syn thymine-thymine dimer (TT dimer) by inserting two As opposite the two Ts of the dimer. Pol{eta
