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  • 标题:Siah-1 binds and regulates the function of Numb
  • 本地全文:下载
  • 作者:Laurent Susini ; Brent J. Passer ; Nathalie Amzallag-Elbaz
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2001
  • 卷号:98
  • 期号:26
  • 页码:15067-15072
  • DOI:10.1073/pnas.261571998
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The Drosophila Seven in absentia (Sina) gene product originally was described as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah-1, recently was found to be involved in p53-dependent and -independent pathways of apoptosis and G1 arrest. We report that Siah-1 interacts directly with and promotes the degradation of the cell fate regulator Numb. Siah-1-mediated Numb degradation leads to redistribution of endogenous cell-surface Notch to the cytoplasm and nucleus and to augmented Notch-regulated transcriptional activity. These data imply that through its ability to target Numb for degradation, Siah-1 can act as a key regulator of Numb-related activities, including Notch signaling.
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