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  • 标题:Multiple mutations and cancer
  • 本地全文:下载
  • 作者:Lawrence A. Loeb ; Keith R. Loeb ; Jon P. Anderson
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2003
  • 卷号:100
  • 期号:3
  • 页码:776-781
  • DOI:10.1073/pnas.0334858100
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Most human tumors are highly heterogenous. We have hypothesized that this heterogeneity results from a mutator phenotype. Our premise is that normal mutation rates are insufficient to account for the multiple mutations found in human cancers, and, instead, that cancers must exhibit a mutator phenotype early during their evolution. Here, we examine the current status and implications of the mutator phenotype hypothesis for the prognosis, treatment, and prevention of human cancers.
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