期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：1
页码：303-308
DOI：10.1073/pnas.012610299
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor {delta} (PPAR{delta}) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPAR{delta}-/- mice exhibit a striking reduction in adiposity relative to wild-type levels. This effect is not reproduced in mice harboring an adipose tissue-specific deletion of PPAR{delta
