期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：11
页码：7705-7710
DOI：10.1073/pnas.092034699
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Endogenous metals may contribute to the accumulation of amyloid plaques in Alzheimer's disease. To specifically examine the role of synaptic zinc in the plaque accumulation, Tg2576 (also called APP2576) transgenic mice (hAPP+) expressing cerebral amyloid plaque pathology were crossed with mice lacking zinc transporter 3 (ZnT3-/-), which is required for zinc transport into synaptic vesicles. With aging, female hAPP+:ZnT3+/+ mice manifested higher levels of synaptic zinc, insoluble amyloid {beta
