期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：13
页码：8850-8855
DOI：10.1073/pnas.132519299
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Mice exposed to aerosolized ovalbumin (OVA) develop increased airway responsiveness when deficient in {gamma}{delta} T cells. This finding suggests that {gamma}{delta} T cells function as negative regulators. The regulatory influence of {gamma}{delta} T cells is evident after OVA-sensitization and -challenge, and after OVA-challenge alone, but not in untreated mice. With aerosolized Abs to target pulmonary T cells, we now demonstrate that negative regulation of airway responsiveness is mediated by a small subpopulation of pulmonary {gamma}{delta} T cells. These cells express V{gamma}4 and depend in their function on the presence of IFN-{gamma} and MHC class I. Moreover, their effect can be demonstrated in the absence of {beta} T cells. This novel type of negative regulation seems to precede the development of the adaptive, antigen-specific allergic response.
