期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：19
页码：12167-12172
DOI：10.1073/pnas.182426799
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Complex chromosome aberrations are characteristically induced after exposure to low doses of densely ionizing radiation, but little is understood about their formation. To address this issue, we irradiated human peripheral blood lymphocytes in vitro with 0.5 Gy densely ionizing -particles (mean of 1 -particle/cell) and analyzed the chromosome aberrations produced by using 24-color multiplex fluorescence in situ hybridization (M-FISH). Our data suggest that complex formation is a consequence of direct nuclear -particle traversal and show that the likely product of illegitimate repair of damage from a single -particle is a single complex exchange. From an assessment of the "cycle structure" of each complex exchange we predict -particle-induced damage to be repaired at specific localized sites, and complexes to be formed as cumulative products of this repair.
