期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：24
页码：15661-15668
DOI：10.1073/pnas.202608299
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers. The results indicate that HCV spread outpaces the T cell response and that HCV rapidly induces but is not controlled by IFN-/{beta}; that viral clearance follows the entry and accumulation of HCV-specific IFN-{gamma}-producing T cells in the liver; and that it may not require the destruction of infected cells.
