期刊名称:Proceedings of the National Academy of Sciences
印刷版ISSN:0027-8424
电子版ISSN:1091-6490
出版年度:2002
卷号:99
期号:4
页码:1910-1914
DOI:10.1073/pnas.032594399
语种:English
出版社:The National Academy of Sciences of the United States of America
摘要:Both in yeast and humans, DNA polymerase (Pol) {eta} functions in the error-free replication of UV-damaged DNA, and Pol{eta} has the unique ability to efficiently replicate through a cis-syn thymine-thymine (T-T) dimer by inserting two As opposite the two Ts of the dimer. Although human DINB1-encoded Pol{kappa} belongs to the same protein family as Pol{eta