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  • 标题:Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini
  • 本地全文:下载
  • 作者:M. Todd Washington ; Robert E. Johnson ; Louise Prakash
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2002
  • 卷号:99
  • 期号:4
  • 页码:1910-1914
  • DOI:10.1073/pnas.032594399
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Both in yeast and humans, DNA polymerase (Pol) {eta} functions in the error-free replication of UV-damaged DNA, and Pol{eta} has the unique ability to efficiently replicate through a cis-syn thymine-thymine (T-T) dimer by inserting two As opposite the two Ts of the dimer. Although human DINB1-encoded Pol{kappa} belongs to the same protein family as Pol{eta
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