文章基本信息

标题：Profound defects in pancreatic β-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1α, and Hnf-3β
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作者：David Q. Shih ; Markus Heimesaat ; Satoru Kuwajima 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2002
卷号：99
期号：6
页码：3818-3823
DOI：10.1073/pnas.062605899
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Defects in pancreatic {beta}-cell function contribute to the development of type 2 diabetes, a polygenic disease that is characterized by insulin resistance and compromised insulin secretion. Hepatocyte nuclear factors (HNFs) -1, -3{beta
关键词：hepatocyte nuclear factors‖diabetes mellitus‖insulin secretion‖ pancreatic islets