期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2003
卷号：100
期号：20
页码：11378-11381
DOI：10.1073/pnas.1534554100
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Dynamic force spectroscopy of single molecules is described by a model that predicts a distribution of rupture forces, the corresponding mean rupture force, and variance, which are all amenable to experimental tests. The distribution has a pronounced asymmetry, which has recently been observed experimentally. The mean rupture force follows a (lnV)2/3 dependence on the pulling velocity, V, and differs from earlier predictions. Interestingly, at low pulling velocities, a rebinding process is obtained whose signature is an intermittent behavior of the spring force, which delays the rupture. An extension to include conformational changes of the adhesion complex is proposed, which leads to the possibility of bimodal distributions of rupture forces.
