期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：20
页码：7560-7565
DOI：10.1073/pnas.0304091101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Heterotrimeric G protein {alpha} (G{alpha}) subunits possess intrinsic GTPase activity that leads to functional deactivation with a rate constant of {approx}2 min-1 at 30{degrees}C. GTP hydrolysis causes conformational changes in three regions of G{alpha
