期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：21
页码：7994-7998
DOI：10.1073/pnas.0401593101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：I{kappa}B kinase (IKK), discovered as the major activator of NF-{kappa}B, plays additional roles in signaling. By using mouse embryo fibroblasts (MEFs) lacking both the {alpha} and {beta} subunits of IKK, we find that these proteins are required for induction of a major subset of IFN{gamma}-stimulated genes and that this requirement is independent of NF-{kappa}B activation. Furthermore, there is no defect in IFN{gamma}-stimulated signal transducer and activator of transcription 1 (Stat1) activation or function in the IKK{alpha}/{beta}-null MEFs. Therefore, although activated Stat1 dimers are necessary for the activation of these genes in response to IFN{gamma
