期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：21
页码：8017-8021
DOI：10.1073/pnas.0401733101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Inhibitor of {beta}-catenin and T cell factor (ICAT) inhibits Wnt signaling by interfering with the interaction between {beta}-catenin and T cell factor. Here we show that ICAT-/- embryos exhibit malformation of the forebrain and craniofacial bones and lack the kidney. Analysis of the neuronal differentiation of embryonic stem cells revealed that Wnt3a redirects the fate of neural progenitors to a posterior character, whereas ICAT induces forebrain cells by inhibiting Wnt signaling. Furthermore, ICAT-/- embryonic stem cells were found to differentiate into neuronal cells possessing a posterior character. These results suggest that ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling.
