期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：30
页码：11082-11087
DOI：10.1073/pnas.0403916101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The private {alpha}-chains of IL-2 and IL-15 receptors (IL-2R and IL-15R) share the signaling {beta}- and {gamma}c-subunits, resulting in both common and contrasting roles of IL-2 and IL-15 in T cell function. Knowledge of the cytokine-dependent subunit assembly is indispensable for understanding the paradox of distinct signaling capacities. By using fluorescence resonance energy transfer and confocal microscopy, we have shown that IL-2R{alpha
