期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：32
页码：11725-11730
DOI：10.1073/pnas.0402374101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in two breeds from the collie lineage. We exploited breed phylogeny and reports of drug sensitivity to survey other purebred populations that might be genetically at risk. We found that the same allele, mdr1-1{Delta
关键词：allele age ; Canis familiaris ; drug sensitivity ; identity by descent ; P-glycoprotein
