期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：32
页码：11827-11832
DOI：10.1073/pnas.0403364101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Murine leukemia viruses (MLVs) have been classified as N-tropic (N-MLV) or B-tropic (B-MLV), depending on their ability to infect particular mouse strains. The early phase of N-MLV infection is blocked in the cells of several mammalian species, including humans. This block is mediated by a dominant host factor that targets the viral capsid soon after virus entry into the cell has been achieved. A similar block to HIV-1 in rhesus monkey cells is mediated by TRIM5{alpha}. Here we show that human TRIM5{alpha} is both necessary and sufficient for the restriction of N-MLV in human cells. Rhesus monkey TRIM5{alpha
