期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2004
卷号：101
期号：46
页码：16216-16221
DOI：10.1073/pnas.0407188101
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：RNA interference was used to screen 3,314 Drosophila double-stranded RNAs, corresponding to {approx}25% of Drosophila genes, for genes that affect the development of the embryonic nervous system. RNA-interference-mediated gene silencing in Drosophila embryos resulted in loss-of-function mutant phenotypes for 43 genes, which is 1.3% of the genes that were screened. We found 18 genes that were not known previously to affect the development of the nervous system. The functions of some of the genes are unknown. Other genes encode protein kinases, transcription factors, and signaling proteins, as well as proteins with other functions.
关键词：embryonic nervous system ; neural mutants ; neural development
