期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：16
页码：6784-6789
DOI：10.1073/pnas.0902018106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：There are more than 50 class I MHC (MHCI) molecules in the mouse genome, some of which are now known to be expressed in neurons; however, the role of classical MHCI molecules in synaptic plasticity is unknown. We report that the classical MHCI molecules, H2-Kb and H2-Db, are co-expressed by Purkinje cells (PCs). In the cerebellum of mice deficient for both H2-Kb and H2-Db (KbDb-/-), there is a lower threshold for induction of long-term depression (LTD) at parallel fiber to PC synapses. This change may be a result of additional glutamate release observed at KbDb-/- CF to PC synapses, which are thought to "train" the cerebellar circuit. A behavioral correlate of cerebellar LTD is motor learning; acquisition and retention of a Rotarod behavioral task is significantly better in KbDb-/- mice than in WT cohorts. These physiological and behavioral phenotypes in KbDb-/- mice reveal a surprising role for classical MHCI molecules in synaptic plasticity and motor learning.
关键词：cerebellum ; neuronal MHC class 1 ; synaptic plasticity
