期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：23
页码：9368-9372
DOI：10.1073/pnas.0812109106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The control of tyrosine phosphorylation depends on the fine balance between kinase and phosphatase activities. Protein tyrosine phosphatase 1B (PTP-1B) and T cell protein tyrosine phosphatase (TC-PTP) are 2 closely related phosphatases known to control cytokine signaling. We studied the functional redundancy of PTP-1B and TC-PTP by deleting 1 or both copies of these genes by interbreeding TC-PTP and PTP-1B parental lines. Our results indicate that the double mutant (tcptp-/-ptp1b-/-) is lethal at day E9.5-10.5 of embryonic development with constitutive phosphorylation of Stat1. Mice heterozygous for TC-PTP on a PTP-1B-deficient background (tcptp+/-ptp1b-/-) developed signs of inflammation. Macrophages from these animals were highly sensitive to IFN-{gamma
关键词：immune system ; interferon gamma ; lymphocyte development ; protein tyrosine phosphatase
