期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：24
页码：9619-9624
DOI：10.1073/pnas.0812367106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Mammalian signaling networks contain an abundance of negative feedback regulators that may have overlapping ("fail-safe") or specific functions. Within the NF-{kappa}B signaling module, I{kappa}B{alpha} is known as a negative feedback regulator, but the newly characterized inhibitor I{kappa}B{delta} is also inducibly expressed in response to inflammatory stimuli. To examine I{kappa}B{delta}'s roles in inflammatory signaling, we mathematically modeled the 4-I{kappa}B-containing NF-{kappa}B signaling module and developed a computational phenotyping methodology of general applicability. We found that I{kappa}B{delta
