期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：34
页码：14391-14396
DOI：10.1073/pnas.0907357106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Approximately 50% of cancer patients receive radiation treatment, either alone or in combination with other therapies. Tumor hypoxia has long been associated with resistance to radiation therapy. Moreover, the expression of hypoxia inducible factors HIF1{alpha} and/or HIF2{alpha} correlates with poor prognosis in many tumors. Recent evidence indicates that HIF1{alpha} expression can enhance radiation-induced apoptosis in cancer cells. We demonstrate here that HIF2{alpha} inhibition promotes tumor cell death and, in contrast to HIF1{alpha
