首页    期刊浏览 2024年11月30日 星期六
登录注册

文章基本信息

  • 标题:HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
  • 本地全文:下载
  • 作者:Jessica A. Bertout ; Amar J. Majmundar ; John D. Gordan
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2009
  • 卷号:106
  • 期号:34
  • 页码:14391-14396
  • DOI:10.1073/pnas.0907357106
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Approximately 50% of cancer patients receive radiation treatment, either alone or in combination with other therapies. Tumor hypoxia has long been associated with resistance to radiation therapy. Moreover, the expression of hypoxia inducible factors HIF1{alpha} and/or HIF2{alpha} correlates with poor prognosis in many tumors. Recent evidence indicates that HIF1{alpha} expression can enhance radiation-induced apoptosis in cancer cells. We demonstrate here that HIF2{alpha} inhibition promotes tumor cell death and, in contrast to HIF1{alpha
  • 关键词:cancer ; ROS ; IR ; Hypoxia ; DNA Damage
国家哲学社会科学文献中心版权所有