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  • 标题:Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
  • 本地全文:下载
  • 作者:M. Sloan Siegrist ; Meera Unnikrishnan ; Matthew J. McConnell
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2009
  • 卷号:106
  • 期号:44
  • 页码:18792-18797
  • DOI:10.1073/pnas.0900589106
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for virulence of Mycobacterium tuberculosis, although its precise function during infection remains unclear. Esx-3, a paralogous system present in all mycobacterial species, is required for growth in vitro. Here, we demonstrate that mycobacteria lacking Esx-3 are defective in acquiring iron. To compete for the limited iron available in the host and the environment, these organisms use mycobactin, high-affinity iron-binding molecules. In the absence of Esx-3, mycobacteria synthesize mycobactin but are unable to use the bound iron and are impaired severely for growth during macrophage infection. Mycobacteria thus require a specialized secretion system for acquiring iron from siderophores.
  • 关键词:secretion ; siderophore
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