期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：45
页码：18972-18977
DOI：10.1073/pnas.0910439106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：NF-{kappa}B is a key activator of inflammatory and immune responses with important pathological roles in cancer, heart disease, and autoimmune diseases. Transcriptional activity of NF-{kappa}B is regulated by different posttranslational modifications. Here, we report a novel mechanism of NF-{kappa}B regulation through lysine monomethylation by SET9 methyltransferase. Set9 specifically methylates p65 at lysine 37. Both TNF{alpha} and IL-1{beta} treatments induced methylation of p65. Methylated p65 is restricted to the nucleus and this modification regulates the promoter binding of p65. Moreover, Set9 mediated methylation of p65 is required for the expression of a subset of NF-{kappa}B target genes in response to TNF{alpha} stimulation.
