期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：48
页码：20399-20404
DOI：10.1073/pnas.0911921106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Ischemia induces the production of angiogenic cytokines and the homing of bone-marrow-derived angiogenic cells (BMDACs), but these adaptive responses become impaired with aging because of reduced expression of hypoxia-inducible factor (HIF)-1{alpha}. In this study, we analyzed the effect of augmenting HIF-1{alpha} levels in ischemic limb by intramuscular injection of AdCA5, an adenovirus encoding a constitutively active form of HIF-1{alpha
