期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：49
页码：20877-20882
DOI：10.1073/pnas.0911796106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Both activated and resting CD4+ T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin {alpha}4{beta}7 ({alpha}4{beta}7), the gut mucosal homing receptor. We find that {alpha}4{beta}7high CD4+ T cells are more susceptible to productive infection than are {alpha}4{beta}7low-neg CD4+ T cells in part because this cellular subset is enriched with metabolically active CD4+ T cells. {alpha}4{beta}7high CD4+ T cells are CCR5high and CXCR4low; on these cells, {alpha}4{beta}7 appears in a complex with CD4. The specific affinity of gp120 for {alpha}4{beta}7 provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission.
