期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2009
卷号：106
期号：49
页码：20918-20923
DOI：10.1073/pnas.0911509106
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Dendritic cells (DC) are the professional antigen presenting cells (APC) that bridge the innate and adaptive immune system. Previously, in a CD11c/EYFP transgenic mouse developed to study DC functions, we anatomically mapped and phenotypically characterized a discrete population of EYFP+ cells within the microglia that we termed brain dendritic cells (bDC). In this study, we advanced our knowledge of the function of these cells in the CD11c/EYFP transgenic mouse and its chimeras, using acute stimuli of stereotaxically inoculated IFN{gamma} or IL-4 into the CNS. The administration of IFN{gamma} increased the number of EYFP+bDC but did not recruit peripheral DC into the CNS. IFN{gamma
