期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1973
卷号：70
期号：12
页码：3759-3763
DOI：10.1073/pnas.70.12.3759
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Veratridine, an activator of action potential Na+ ionophores, stimulated passive Na+ uptake by electrically excitable neuroblastoma and muscle cells but had no effect on clonal cell lines defective in Na+-ionophore activity. Veratridine-dependent Na+ uptake was completely inhibited by tetrodotoxin, a specific inhibitor of the action potential Na+ ionophore. Half-maximal inhibition was obtained with 11 nM tetrodotoxin. Thus, veratridinedependent Na+ uptake provides a specific and convenient means of assaying populations of cultured cells for action potential Na+-ionophore activity.
