期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：1974
卷号：71
期号：4
页码：1504-1505
DOI：10.1073/pnas.71.4.1504
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Substitution of the N-terminal amino groups with pyridoxal compounds inhibits gelation and increases the solubility of deoxy sickle hemoglobin (Hb S). Pyridoxylation of the [α] chains has considerably more effect than that of the {beta} chains. The increase in minimum gelling concentration of Hb S that results from modification of the [α] N-termini is the same as that produced by dilution of Hb S with an equal amount of Hb A.
关键词：α and β N-terminal amino groups ; pyridoxal phosphate ; pyridoxal sulfate ; hemoglobin solubility
